effect of diabetes on neuro muscular transmission

ABSTRACT

This work included clinical and experimental studies. The clinical study included ten normal females as controls and ten uncontrolled diabetic females who did not receive insulin therapy before. Estimation of fasting blood glucose, fasting serum insulin and measurement of hand grip strength before and after treatment with insulin were done. The results demonstrated that diabetes produce marked weakness of the hand grip strength which improves markedly after insulin therapy. The experimental study was carried on rat phrenic diaphragm preparations taken from normal rats and alloxan diabetic rats. Fasting blood glucose and serum insulin levels were determined, then the time needed to induce neuro muscular block was calculated when indirectly stimulated at a rate of 1 impulse/second and 5 impulses/second. Five experiments were done after addition of insulin to the bath in diabetic rats. It can be concluded that the time is much shortened in diabetic rats and significantly prolonged after addition of insulin to the bath