Predictive value of plasma fibronectin levels in pregnant women destined to have preeclampsia

ABSTRACT

Plasma fibronection level of 41 normotensive primigravida was measured repeatedly during their antenatal visits, with total 76 samples. Plasma fibronectin of 12 normotensive primigravida who subsequently developed preeclampsia was found to be significantly higher if compared with those who did not develop preeclampsia [P<0.001]. The results of this study indicate that if an increase of plasma fibronectin more than 400 microgram/ml [used as cutoff level], subsequent development of preeclampsia within an average of 3.3 weeks could be predicted with sensitivity of 92.3 percent, and specificity of 96.8 percent