Prognostic factors in renal adenocarcinoma

ABSTRACT

This retrospective study of 43 cases of renal cell carcinoma showed an overall actuarial four-year survival of 52.6 percent, stage I100 percent, stage II 75 percent, stage III 40.2 percent, and stage IV 0 percent. High grade tumours gave 38.2 percent 4-year survival compared to 59 percent for low grade tumours. There was no significant difference in four-year survival of patients with either clear or granular cell types [69.6 percent and 58.1 percent respectively], while the sarcomatoid cell type had the worst prognosis [33.3 percent]. However, the histopathologic pattern did not influence survival. Survival had significantly decreased as tumour invaded perinephric fat [28 percent] or regional lymph nodes [27.3 percent]. However, renal vein involvement [34.3 percent] did not significantly affect the survival rates. Because the clinical manifestations and natural history of renal cell carcinoma are so varied, long term follow up is essential to understand better the disease and the efficacy and the available modes of therapy