Thyroid hormones and lipid propofol in nephrotic children before and after steroid therapy

ABSTRACT

Thyroid hormones and serum lipids, Apolipoproteins and kidney function tests were determined in 20 children with lipoid nephritis in comparison to 10 healthy controls of matchable age. Children were studied during an active phase of the disease and in a remission phase following prednisolone therapy for 2-4 weeks. Before therapy cases showed significantly lower levels of Tetraiodo-Thyronine [T4] and insignificantly lower level of triiodothyronine [T3] than controls, after therapy these levels raised. The post treatment level of T4 was significantly higher than its pretherapy level and the post treatment level of T3 was significantly higher than that of controls. Thyrotropin [TSH] was insignificantly higher in cases before treatment than in controls and decreased significantly after treatment to become insignificantly lower than controls. Before treatment cases showed significantly higher levels of cholesterol, low density lipoprotein [LDL-C] and insignificantly higher apolipo protein -B [apo-B] than controls. After treatment cholesterol level was significantly lower than pretreatment level and became significantly higher compared to controls, LDL-C showed no significant change after treatment and remain significantly higher compared to controls, apo-B showed insignificantly change after treatment. Before therapy the levels of high density lipoprotein [HDL-C] and apo-A were insignificantly lower than these of controls. After therapy HDL-C rised significantly than the pretreatment level and became significantly higher than that of controls. Apo-A significantly rised than pretreatment levels and remained different from that of controls. In the cases the levels of serum albumin before treatment was significantly lower than controls, it rised significantly after treatment to be similar to that of controls