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Effect of lactulose and neomycin on plasma level of prostaglandin E in patients with portasystemic encephalopathy
New Egyptian Journal of Medicine [The]. 1992; 6 (5): 1266-1270
in English | IMEMR | ID: emr-25470
ABSTRACT
This work aimed at the study of the relation of plasma prostaglandin E [PGE] to the development of chronic portosystemic encephalopathy [PSE] in patients with chronic liver disease and its response to treatment with either lactulose or neomycin. The study included 30 patients with chronic liver disease and PSE and 10 healthy controls. PGE plasma levels were assayed using radioimmunoassay [RIA] at the beginning of the study and 14 days after treatment with either lactulose [15 patients] or neomycin [15 patients]. PGE mean levels were higher in patients with chronic liver disease and PSE in comparison to controls [11.61 +/- 5.2 versus 1.88 +/- 1.16 ng/ml respectively, P < 0.05]. The overall result of treatment with either lactulose or neomycin was a reduction from 11.61 +/- 5.2 to 9.85 +/- 4.42 ng/ml. [P < 0.05]. Ascitic patients had higher PGE levels than non ascitic patients before [14.05 +/- 3.74 vs 8.42 +/- 4.78 respectively] and after treatment [10.99 +/- 3.74 vs 8.92 +/- 4.92]. Neomycin resulted in a decrease in PGE levels only in the ascitic group from 16.2 +/- 3.77 to 11.9 +/- 4.69 ng/ml. [P < 0.05] while lactulose did not significantly alter the PGE level in ascitic or non ascitic patients. It is concluded that PGE levels are increased in patients with PSE and that their level increases more with the degree of hepatic decompensation. Neomycin significantly decreases PGE levels in ascitic patients while lactulose did not significantly influence PGE levels. PGE may not be used as a marker of PSE since all patients showed clinical improvement with either lactulose or neomycin
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Index: IMEMR (Eastern Mediterranean) Main subject: Neomycin / Prostaglandins / Kidney Function Tests / Lactulose / Liver Function Tests Language: English Journal: New Egypt. J. Med. Year: 1992

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Index: IMEMR (Eastern Mediterranean) Main subject: Neomycin / Prostaglandins / Kidney Function Tests / Lactulose / Liver Function Tests Language: English Journal: New Egypt. J. Med. Year: 1992