Biochemical and histopathological effects of acute and chronic head trauma on the brain of albino rat

ABSTRACT

Thirty six albino rats were used in this experimental work. They were divided into six groups, each comprised six rats. One group was considered as control, two groups were exposed to acute head trauma and the other three groups to chronic head trauma. The animals were decapitated after different periods of time. Serotonin level of the brain tissue was estimated and the brains were examined histopathologically. It was found that there was significant increase in serotonin level in cases of chronic head trauma while the increase was insignificant in acute cases. The histopathological examination of the brain showed more serious changes in chronic head trauma than in acute