Evaluation of argyrophilic nucleolar organizer regions [NORs] in hodgkin's disease in the head and neck region

ABSTRACT

In the present study, subjects of Hodjkin's disease [HD] presenting in the head and neck region, were investigated using the AgNORs technique. Quantification of AgNORs staining will allow one to obtain comparative information directly from paraffin section among subtypes of HD. In this study, the AgNORs in both R-S cells and the cellular background were counted/cell in twenty cases of HD, presenting in the head and neck region. From this study it could be concluded that -At the statistical level, there is an overall agreement with the grading efficiency of the Rye classification. However, AgNOR count might be considered an objective biologic parameter independent of the histological grading at the level of evaluating an individual case.- There is a striking variation in the proliferative activity of the R-S cells in some of the Lymphocytic predominant [LP] cases of HD. It is suggested that the Mixed cellularity [MC] and Lymphocytic depletion [LD] subtypes may be of nearly similar biology potentiality. - The comparatively increased AgNORs count in the surrounding background in some cases might indicate an increased proliferative activity, the nature of which is different from that of the hyperplastic lymph nodes