Serum soluble interleukin-2 receptors in patients with acute post streptococcal glomerulonephritis

ABSTRACT

Serum soluble interleukin-2 receptor [SIL-2R] concentrations were determined in 14 children with acute post streptococcal glomerulonephritis [APSGN] and 10 healthy children of matched age and sex, utilizing ELISA method. The results showed that serum SIL-2R concentration in APSGN cases were significantly higher than in healthy controls and tend to decrease after clinical and urinary improvement. It was found that SIL-2 were negatively correlated with systolic blood pressure and ESR. Moreover, a significant positive correlation between SIL-2 and creatinine clearance was found. These findings suggested that serum SIL-2R can serve as an indicator of activity of APSGN and higher values associated with less morbidity