Efficacy of probucol in cases of hypertriglyceridemia

ABSTRACT

It has been reported by some workers that probucol has no effect on triglyceride level, meanwhile other reported greater reduction in triglyceride level with familial hyperlipidemia, especially with apolipoprotein E4. In this trial, the effect of probucol [A hypocholesterolemic agent] on serum triglyceride was further examined. Thirty-two patients were included in this study; 24 of them showed reduction of triglyceride after 2 weeks treatment with 500 mg probucol twice daily from 347 mg/dL to 243 mg/dL [29.9%]. Diabetic patients [14 cases] showed less response on the same dose from 385.5 mg% to 298 mg% [22.6%]. Six patients showed reduction only after increasing the dose to 500 mg TDS for 4 weeks from 337 mg/dL to 303 mg/dL [10%]. Two patients did not show response and were switched to clofibrate. Probucol is effective in lowering triglyceride as well as cholesterol Levels