Cytogenetic effect of consecutive doses of a constant magnetic field I-induction of micronuclei in bone-marrow cells in mice

ABSTRACT

The cytogenetic effect of a constant magnetic field [400G] was studied with the micronucleus test in mice bone marrow. Adult male mice were exposed to 5 consecutive doses, each separated by 24-hour intervals, for 30 minutes. All doses induced a significant increase in the number of micronucleated polychromatic erythrocytes [PCE]. The highest micronuclei were observed after exposure to double, while the lowest micronuclei were after pentad dose. Moreover, the dose response effect showed that the increase in micronuclei was linearly up to double dose and, thereafter, the increases dropped and slightly deviated from linearity. In conclusion, the clastogenic and/or aneugenic effects, observed in this study, of magnetic field may be closely correlated with cell transformation, tumorigenesis and aneuploidy