Anticardiolipin antibodies in children under chronic hemodialysis efficacy

ABSTRACT

IgG and IgM anticardiolipin antibodies [aCL] concentrations were determined in serum samples of 48 children with ESRD on hemodialysis using ELISA technique in an attempt to analyze their possible role in the occurrence of thrombosis of the vascular access. 10 normal healthy children were studied as a control group. The positivity of both IgG-aCL and IgM-aCL isotypes were high in hemodialysis patients. The mean values of GPL units was 25.7 +/- 10 and 9.4 +/- 3.1 for MPL units. Children with positive levels of aCL had significantly more prior thrombosis of vascular access. A strong negative correlation between platelet count and positive aCL titers was found. Negative correlation was also appeared between platelet count and occurrence of fistula thrombosis. Elevated positive levels of aCL are common in children with ESRD on hemodialysis and should be interpreted as markers of risk for fistula thrombosis, and may be useful in prediction of subsequent vascular occlusive events