Propafenone in experimentally induced acute myocardial infarction

ABSTRACT

In the present work, the effect of propafenone on experimental acute myocardial ischemia induced by either total left coronary artery [LCA] ligation [persistent and transient for 30 and 60 minutes] or by s.c. injection of isoprenaline [300 mg/kg] was investigated in albino rats. Propafenone was given as a single selected for evaluation of the severity of ischemia and the effect of propafenone were the voltage of T-wave, the heart rate, the CK-MB enzyme serum level and the percent of infarct area. In addition, the effect of propafenone on the coronary outflow in vitro was, also, investigated on the rabbit heart. The present work demonstrated that propafenone produced significant decrease in almost all examined parameters, when it was given before or after induction of ischemia. However, pretreatment with propafenone produced significantly greater effects as compared with those produced when the drug was administered after induction of ischemia. Such finding suggested a protective rather than a curative effect for propafenone against myocardial damage caused by ischemia. Investigating the effect of propafenone on the isolated perfused rabbit heart revealed a significant increase in the coronary outflow, which could, in part, explain the cardioprotective effect of this drug in myocardial ischemia