Cyanoacrylate tissue adhesive versus suturing in wound closure

ABSTRACT

The purpose of this study was to compare histologically the use of a tissue adhesive [N. Butyl-2-cyanoacrylate] versus sutures in sixteen adult albino rats. Two incisions were made in the either side of the tongue, approximately 2 cm. in length. The right side was used as a control and closure was attained by 4/0 silk sutures, the left side was used as the experimental site. Another similar procedure was done on the either side of the skin of the same rat. Groups of 4 animals were sacrificed at 2, 7, 14 and 21 days postoperatively. In this experiment, it was shown that, where the use of cyanoacrylate as tissue adhesive did not produce any deleterious effects and well tolerated by the tissues. The healing with the tissue adhesive on wounds gave similar results to the suture side but the healing was more rapid on suture aite. There is no difference between the healing with cyanoacrylate on both tongue and skin wound. Also the present investigation revealed that the formed epithelium in glued side was more regular than the suture side. We can conclude that cyanoacrylate is as effective as suture in oro-facial wound closure and not superior to it