Histopathologic changes induced by chronic exposure to a household insecticide: an experimental study

ABSTRACT

The effect of chronic exposure to a household insecticide on the liver, kidneys, lungs, heart and spleen of albino mice was studied. Histopathologic liver changes; in the form of sinusoidal dilatation, hepatocellular atrophy and centrilobular necrosis, were observed. About 10% of the exposed animals showed hyperplasia of the epithelial lining of the bile ductules with occasional papillomatous formation. The kidneys showed parenchymatous degeneration and necrotic changes in the proximal convoluted tubules. Congestion of the capillary bed of the lung and emphysematous changes were noticed. However, there was no obvious histopathologic changes in the various other organs of the present study. The results were analysed, and compared with those of the literature; and, the possible hazards of human exposure to household insecticides were discussed