suppressive effect of green tea extract of chromosome aberrations induced by yeast killer toxin [KT 36] in rat bone marrow cells

ABSTRACT

Soil samples collected from the different sites in Zagazig area yielded isolation of yeast killer fungi [Hansenula anomala]. Yeast killer toxin [KT 36] from Hansenula anomala fungus induced chromosomes aberrations [CA] in rat bone marrow cells. The incidence of aberrant cells were at their maximum level 24 hours after toxin injection. Rats given the hot water extract from green tea [GTE] 24 h before they were injected with [KT 36] displayed considerably suppressed [KT 36] induced [CA] in their bone marrow cells. Rats administered [GTE] 2 h before or after [KT 36] induced [CA] parallel the dose of [GTE] when given in the range between 0.1 and 2 gm/kg body weight; higher doses produced no additional suppression. On the other h and, rats given the hot water extract from black tea or coffee 24 or 2 h before yeast toxin injection showed no suppressive effect