Prostaglandin E, cortisol and thyroid hormones in cases of rhinoscleroma

ABSTRACT

Prostaglandin E, cortisol and T[3] and T[4] were assayed in sera of rhinoscleromatous patients [40 subjects], contacts [20 subjects] and controls [20 subjects]. Prostaglandin E was found significantly elevated [P < 0.001] in patients with rhinoscleroma as compared to controls. This finding can be explained on the ground of increased production at the site of inflammatory process and its transport to blood. No changes were reported in contacts [P > 0.05]. Statistically significant changes were not found when cortisol levels were considered [P > 0.05]. Cortisol is known to be correlated with prostaglandin only when given in therapeutic doses, but in this work all patients and contacts were not under steroid therapy. Thyroid hormones were also not changed in group II and III subjects [P > 0.05]. It appears that there is no role of prostaglandin-which are increased in rhinoscleroma-in thyroid hormones production in euthyroid subjects as it can only induce thyroid hormones production in hyperthyroid subjects: