effect of some cyclooxygenase inhibitors on picrotoxin induced convulsions in mice

ABSTRACT

The present study was designed to study the effect of pre-treatment with the cyclooxygenase inhibitors non-steroidal anti-inflammatory drugs [NSAIDS]; indomethacin, ketoprofen and tiaprofenic acid on the picrotoxin-induced seizures in albino mice. Picrotoxin was injected i.p in two doses of 8 and 16 mg/kg one hour after i.p injection of indomethacin [25 mg/kg], ketoprofen [100 mg/kg] or tiaprofenic acid [200 mg/kg]. Convulsions were assessed by the following parameters the protection from convulsions, the time to onset of colonic or tonic seizures, the duration of convulsion [terminated by death] and the incidence of death occurring in one hour. The results of the present work demonstrated that non of the fore mentioned parameters for assessment of seizures induced by 8 or 16 mg/kg picrotoxin were significantly changed by prior administration of indomethacin, ketoprofen and tiaprofenic acid indicating that prostaglandins are not involved in such process