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effect of some cyclooxygenase inhibitors on picrotoxin induced convulsions in mice
Zagazig Medical Association Journal. 1992; 5 (3): 275-282
in English | IMEMR | ID: emr-26750
ABSTRACT
The present study was designed to study the effect of pre-treatment with the cyclooxygenase inhibitors non-steroidal anti-inflammatory drugs [NSAIDS]; indomethacin, ketoprofen and tiaprofenic acid on the picrotoxin-induced seizures in albino mice. Picrotoxin was injected i.p in two doses of 8 and 16 mg/kg one hour after i.p injection of indomethacin [25 mg/kg], ketoprofen [100 mg/kg] or tiaprofenic acid [200 mg/kg]. Convulsions were assessed by the following parameters the protection from convulsions, the time to onset of colonic or tonic seizures, the duration of convulsion [terminated by death] and the incidence of death occurring in one hour. The results of the present work demonstrated that non of the fore mentioned parameters for assessment of seizures induced by 8 or 16 mg/kg picrotoxin were significantly changed by prior administration of indomethacin, ketoprofen and tiaprofenic acid indicating that prostaglandins are not involved in such process
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Index: IMEMR (Eastern Mediterranean) Main subject: Picrotoxin / Seizures / Mice Language: English Journal: Zagazig Med. Assoc. J. Year: 1992

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Index: IMEMR (Eastern Mediterranean) Main subject: Picrotoxin / Seizures / Mice Language: English Journal: Zagazig Med. Assoc. J. Year: 1992