Characterization of piroxicam-cyclodextrins inclusion complexes and their influence on ulcerogenic activity

ABSTRACT

Piroxicam was included into alpha- and beta-cyclodextrins crowns [1 1 molar ratio] to give solid inclusion complexes. Solubility diagrams of piroxicam and cyclodextrins were presented. Spectroscopic analyses [UV and IR] as well as powder X-ray diffractometry were effective tools for further characterization of complexation. Certain physicochemical properties of these complexes [dissolution rate, permeation through cellophane membrane and apparent partition coefficient between organic and those of aqueous phases] were examined and compared with piroxicam alone. The rate of dissolution of piroxicam was significantly increased by the formation of inclusion complexes. The ulcerogenic activity of the drug was also significantly decreased upon complexation especially with beta- cyclodextrin