Spectrophotometric determination of mequitazine

Two simple and sensitive spectrophotometric assay procedures were described for the determination of mequitazine. The first was based on the reaction of the drug with aconitic anhydride to give a red colored product measurable at 547 nm. The second depended on the oxidation of the drug with sodium nitroprusside in the presence of concentrated HCl to give a violet color with a maximum absorbance at 569 nm. Optimization of the experimental conditions was described. The proposed methods were applied to the determination of mequitazine in tablet form