Evaluation of measurement of glucose and protein glycosylation in dried blood spots in diabetic patients

ABSTRACT

Blood glucose and whole blood glycosylation were determined in dry blood spotted on to filter paper, as well as in fresh blood samples obtained from 92 non insulin dependent diabetics and 17 healthy subjects. Blood glucose levels and whole blood glycosylation measured in dried and fresh blood were significantly increased in diabetics compared with controls. Blood glucose levels and whole blood glycosylation in dried blood spots correlated strongly well with the corresponding levels in fresh blood samdples. Since these papers could be wetted with capillary blood from a finger prick, they can be easily used by the patients especially in far rural areas and kept at room temperature until brought to the hospital. The dried blood spot procedure does not add any extra cost to the conventional methods: