Lipid peroxides and some antioxidants as indices of oxidant stress in children with non Hodgkin's lymphoma

ABSTRACT

Oxygen free radicals have been recently suggested to be implicated in the pathogenesis of malignant disorders. Therefore, lipid peroxides as an indicator of oxygen free radical induced damage, together with the enzymatic antioxidants namely ceruloplasmin, superoxide dismutase and the nonenzymatic antioxidant total thiols were determined in sera of 30 children with non Hodgkin 's lymphoma, before any therapeutic intervention. The same bioindices were studied in 20 of these children after completion of their therapeutic regimen together with 10 healthy children representing control group. Lipid peroxides were significantly increased while ceruloplasmin, superoxide dismutase and plasma thiols were significantly decreased in patients compared with healthy children. A significant negative correlation was observed between lipid peroxide levels and ceruloplasmin, superoxide dismutase and total thiols levels. Chemotherapy has no significant effect on the serum levels of the previous bioindices. These results clearly indicates that children with non Hodgkin's lymphoma are under oxidant stress which is manifested by increased lipid peroxides and decreased ceruloplasmin, superoxide dismutase and thiols. This change may contribute to propagation of the malignant process by interfering in the pateint's antitumorous immune surveillance