pattern of bacterial isolates and its sensitivity to antibiotics in chronic obstructive airway disease with exacerbation of infection in upper Egypt

ABSTRACT

This study was carried out on 150 patients having chronic obstructive airway disease. Ninety-six males [64%] and 54 females [36%] with age groups ranged from 20-70 years old. Seventy-six of 96 male patients [79.1%] were smokers either cigarettes or [Goza], most of them [44.6%] consumed 10-20 cigarettes per day, they were classified into 15 patients [10%] having chronic bronchitis, 86 patients [57.3%] having bronchial asthma and 49 patients [32.7%] having emphysema. A sputum sample [purulent or mucopurulent] from each patient was collected in dried and sterilized Petridishes and subjected for various bacteriological investigations [films, cultures and biochemical reactions]. Tuberculous patients were not included in our study. The pneumococci constituted the highest frequency 66 cases 3 [44%], next in frequency the Staphylococcus aureus 53 [35.3%] followed by Branhamella catarrhalis 21 [14%], Klebsiella pneumoniae 13 [8.7%]. Haemophilus influenzae 11 [7.3%], Pseudomonas aeruginosa 5 [3.3%], Microccus tetragenous 4 [2.7%], Streptococcus pyogenes 3 [2%], Acinetobacter pneumoniae 3 [2%] E. coli 2 [1.3%] and yeast 8 [5.3%]. Many of the isolated organisms were present in mixed form. The antibiogram of 100 pure isolates was done. It showed that most of these isolates are sensitive to cefadroxil [duricef], clindamycin [dalacine], cephaloridine [cephalexine], amoxycillin [hiconcil] and cefotoxime [claforan]. On the other hand most of the bacterial isolates were resistant to trimethoprim [bactrim], ampiciliin and chloramphenicol