effect of lidocaine versus nalbuphine hydrochlorides and phenobarbital as permedicants for control of acute intracranial hypertension, experimental study

ABSTRACT

Forty adult male cats were randomly collected and divided into four equal groups. The first group was considered as control, B, C, D groups were pretreated with lidocaine 1.5 mg/kg, nalbuphine 0.5 mg/kg and phenobarbital 0.5 mg/kg. A rubber balloon catheter was inserted extradurally after right craniectomy and inflated by saline as 1 cm bolus every one minute. Intracranial pressure, cerebral perfusion pressure, brain compliance and cerebro-spinal pH were estimated after each bolus saline injection to study and compare the effectiveness of lidocaine, nalbuphine and phenobarbital as premedicants for the brain protection against the rapid increase in the intracranial tension. Results showed that lidocaine was the most protective one, followed by phenobarbital and then nalbuphine. Lidocaine significantly increases the tolerance of the cranial cavity to accept added volumes before the onset of brain ischemia