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T-lymphocyte subsets characterization in hepatosplenic schistosomiasis using monoclonal antibodies
Bulletin of Alexandria Faculty of Medicine. 1993; 29 (4): 665-72
in English | IMEMR | ID: emr-27465
ABSTRACT
Immunohistochemical technique using monoclonal antibodies was applied on the liver tissues of 20 adult Egyptian male patients with compensated hepatosplenic schistosomiasis to characterize the relative distribution of T-lymphocytes subpopulations. Sections showed marked pan T-lymphocytic infiltration [OKT3] with marked relative increment of suppressor/cytotoxic [OKT8] cells over helper/inducer [OKT4] cells. Also, alkaline phosphatase activity showed inverse significant correlation with suppressor/cytotoxic [OKT8] and pan lymphocyte [OKT3] cells. This suggested that suppressor/cytotoxic [OKT8] cells play an important role in modulation of the granuloma with subsequent stabilization of liver condition
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Index: IMEMR (Eastern Mediterranean) Main subject: Schistosomiasis / Immunohistochemistry / Antibodies, Monoclonal Limits: Humans Language: English Journal: Bull. Alex. Fac. Med. Year: 1993

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Index: IMEMR (Eastern Mediterranean) Main subject: Schistosomiasis / Immunohistochemistry / Antibodies, Monoclonal Limits: Humans Language: English Journal: Bull. Alex. Fac. Med. Year: 1993