comparative clinical trial of two once-a month injectable contraceptives [cyclofem and mesigyna]

ABSTRACT

A comparative clinical trial of two once-a-month injectable contraceptives [cyclofem and mesigyna] was carried out in Shatby University Hospital. A total of 297 women [150 for cyclofem and 147 for mesigyna] were recruited in the study and were followed for a period of 12 months. The two groups of women were comparable in all aspects, 86.9% of women continued until the end of 12 months. The contraceptive efficacy for both regimen was 100%. More than 90% of women in both groups did not have any complaints during the 12 follow-up visits. No significant differences was found between the two groups as regards continuation and discontinuation rates, menstrual pattern, blood pressure [systolic and diastolic] and body weight changes. The results showed that cyclofem and mesigyna are highly effective contraceptives that caused side effects in less than 10% of users and were acceptable to women as evidenced by a high continuation rate over the study period