use of some genetic markers in paternity problems

ABSTRACT

The study was carried out on 10 biological families. Each family was composed of a father, a mother and one of their children [5 sons and 5 daughters]. Blood grouping was done for each one. This included 22 red cell antigens of 10 blood group systems in addition to HLA typing class 1 [HLA-A-A, B]. As regards the frequency of the different blood groups and the different HLA-A, -B types, no two similar HLA-A and -B were found in the sample studied. On comparing these results with those of the different blood groups, a significant statistical relation was found, denoting that HLA typing is extremely individual. The relation between blood groups of parents and children in different systems were correlated. This study is needed to be repeated on a wider scale involving a large number of the Egyptian population, to find out the gene frequencies of the different blood groups. This enables a correct interpretation of the probability of paternity results: