Spectrophotometric study on the determination of etilefrine hydrochloride in pure from and in some pharmaceutical formulation

ABSTRACT

A spectrophotometric study on the determination of etilefrine hydrochloride in pure form in some simple pharmaceutical formulations was presented. This study depended upon either direct measurement of the absorbance at 237 nm and at 291 nm, or indirectly by measuring the amplitude height of the first derivative peak at about 245 nm. Both procedures were carried out in alkaline medium of about 0.01 N sodium hydroxide. In compound pharmaceutical formulations containing etilephrine and chlorpheniramine, the direct measurement at 291 nm in alkaline medium is the only successful for the determination of etilefrine. Beer's law is obeyed in the range from 5 to 35 mcg/ml for the direct measurement at 291 nm, and from 5 to 40 mcg/ml for both the direct measurement at 237 nm and for the first derivative technique at about 245 nm