Synthesis of certain period [1,2-c] pyramid [5,4-e] pyrimidines of expected pharmacological interest

ABSTRACT

Five series of the titled nucleus were prepared. Enaminonitrile I reacted with oxalyl chloride and chloroacetyl chloride to afford the tricyclic compounds II and III, respectively. II reacted with various alcohols to give the corresponding ester, also III reacted with various amines to yield the corresponding compounds. The anti-inflammatory effect of some members showed significant results as compared with Diclofenac. Another derivatives were found to inhibit 50% of the histamine induced contraction of guinea pig ileum. It is worth mentioning that the animals treated with the test substances were more quiet and less aggressive than the control