Effect of fluidized bed and high speed mixing granulation on the mechanical properties and bioavailability of trimethoprim

ABSTRACT

Trimethoprim, an antibacterial insoluble drug, was granulated with 10% aqueous PVP solution using fluidized bed granulator and speed mixing. The granules were evaluated according to flowability, tensile strength and porosity, as well as compressibility after compaction into tablets. The prepared tablets were evaluated according to the physical characteristics of tablets and bioavailability of trimethoprim. The results indicated that on using fluidized bed granulation, porosity of the powder was decreased. Good compressibility and good entirely coated granules with the binder were obtained. On the other h and, tablets prepared by the same method of granulation showed that trimethoprim was equally absorbed at the same rate and extent