Recurrent vulva-vaginal candidiasis: Role of the immune system in the pathogenesis

ABSTRACT

A total of 60 patients with recurrent vulvo-vaginal candidiasis [study group] and 20 healthy women [control group] have been evaluated for the T-Iymphocyte function. The study revealed that T-Lymphocyte transformation into blast cell in the patient group [38.8%] is twice low as in the control [80.2%]. A suggested mechanism of this finding is that macrophages in such patients produce prostaglandins which block the T-lymphocytes. So, the study, justifies addition of T-lymphocytes proliferating pentapeptides and prostaglandin Inhibitors in the treatment of recurrent vulvo-vaginal candidiasis