Synthesis of benzopyrono-1,4-oxazines as new tricyclic antidepressant agents

ABSTRACT

A number of benzopyrano [7,6-b], [7,8-b]- and [5,6-b]-1,4-oxazines was synthesized by elaboration of the oxazine ring on a performed substituted benzopyrone nucleus. Six of the final compounds as well as 2 of their precursors, o-acetamidobenzopyron-yloxyketones were found to have an antidepressant like profile in behavioral and calorigenic tests predictive of antidepressant efficacy