Immunohistochemical localization of carcinoembryonic antigen in endocervical glandular lesions

ABSTRACT

Ten cases of microgl and ular hyperplasia and seven cases of adenocarcinoma of endocervical origin were studied by peroxidase- antiperoxidase method [PAP] for the presence of carcinoembryonic antigen [CEA]. Nine of the ten cases of benign lesions were negative and one was focally positive. Five of the seven adenocarcinomas were widely positive and two were focally positive. The results suggested that extensive immunohistochemical positivity for CEA in endocervical gl and ular lesions is indicative of malignancy