Effect of uremic toxins on platelet aggregation and plasma fibrinolysis

ABSTRACT

The uremic syndrome is characterized by the controversy of bleeding tendency and clotting complications. The effect of some uremic toxins on platelet aggregation and plasma fibrinolytic activity, the key stones of coagulation and fibrinolysis was investigated. Urea, creatinine, uric acid, phenol, ammonia, indole and 5-OH tryptamine were found to inhibit platelet aggregation. Urea, creatinine, uric acid and phenol decreased the fibrinolytic activity, whereas aliphatic amines has no effect on either platelet aggregation or fibrinolysis [and also guanidinosuccinic acid]. The possible mechanisms and clinical implications were discussed