Trace elements changes in Parkinson's disease

ABSTRACT

Copper and zinc levels in serum of thirty two patients with parkinsonism syndrome were estimated and were compared to those of thirty normal healthy individuals served as controls. Serum levels of copper but not that of zinc in patients with parkinson's disease were significantly lower than controls [P<0.001]. and this was reflected on the significant low ratio of copper to zinc. There was significant positive correlation between the serum copper and the duration of the disease. These results may give an indication of changes in serum trace elements associated with degenerative process in Parkinson's disease and reflect the duration and implying the prognosis