Effect of alpha tocopherol on the glycerol induced acute renal failure in rats: Biochemical, morphological and hiscopathological assessment

ABSTRACT

The importance of alpha tocopherol acetate administration in determining its beneficial action in glycerol- induced acute failure was investigated by examining the effects of a single dose of alpha tocopherol given immediately [0 h] and at one hour [1 h] before glycerol injection. Alpha tocopherol, when given at 1 h, significantly raised blood urea and serum creatinine concentrations when compared to untreated animals or those that received glycerol or alpha tocopherol. The administration of alpha- tocopherol neither attenuated the increase in kidney weight associated with acute renal failure nor reduced the kidney damage as assessed by histological examination. The results show that single administration of alpha tocopherol afforded no protective effect on renal function