effect of the water extract of flowers of Anchusa Strigosa on the minimal electroshock seizure threshold in mice

ABSTRACT

The effect of the water extract of the flowers of Anchusa strigosa on the minimal electro-shock seizure threshold in mice was investigated. Administration of the extract increased minimal electro shock seizure threshold dose dependently. The effect of the extract on the minimal electro shock seizure threshold persisted up to 6h but disappeared after 24h. The effect of the extract of Anchusa strigosa on the Minimal electro-shock seizure threshold was partially blocked by the benzodiazepine antagonist flumazenil. This indicates that the effect of the extract of Anchusa strigosa is partially mediated by the central type of benzodiazepine receptors