Immunohistopathological study of hepatocutaneous manifestations

ABSTRACT

Thirty three patients, 22 males and 11 females suffering from chronic hepatic disorders and 15 normal controls 13 females and 2 males had been selected for this study. Out of the 33 patients 15 had history of chronic intestinal Bilharziasis, 4 cases have history of viral hepatitis. One case had history of etretinate intake for treating psoriasis one year before onset of acute viral hepatitis. Eleven patients had neither history of hepatitis nor Schistosomiasis. All patients and normal controls were subjected to the following examinations general, skin, liver function tests, serum immunoglobulins, C3, liver biopsy and histopathogical study. Results showed pigmentation in 42 percent of cases, jaundice in 36 percent of cases, pruritus in 38 percent of cases, unguual changes in 39 percent of cases, Lichen planus in 9 percent of cases and psoriasis in 9 percent of cases. The immunological and histopathological findings were discussed