Acute myeloid leukemia-FAB classification and its correlation with clinico-Hematological features

ABSTRACT

The French-American and British [FAB] classification of 62 consecutive cases of acute myeloid leukemia was undertaken. AML-M2 was the commonest FAB type [32.26%], followed by Ml and M4 [22.58% each], M5 [8.6%] and M6 and M7 [1.61% each], respectively. One of the patients was diagnosed as AML-MO [not a FAB type]. The mean age of Ml, M2, M3 and M5 cases was between 25and 29 years, whereas in M4 patients it was 45.6 years. AML-M2, M4 and M5 were commoner in males, Ml in females and M3 equal in both sexes. Feeling of weakness, easy fatiguability and pallor were invariably present in all FAB types. All the patients of Ml and M5, 85% of M2, 64% of M 4 and 50% of M3 presented with fever. Bleeding manifestations were most frequent in M3 cases followed by M5, Ml, M4 and M2, respectively. Hepatomegaly and splenomegaly were relatively less prominent features in M3 as compared to other FAB types. Amongst the haematological parameters, anaemia was more severe in M1, leucocytosis in M2 and thrombocytopenia in M3 cases as compared to other FAB types