Conductometric determination of some pharmaceutically important thiol compounds

ABSTRACT

A simple and sensitive electro-analytical method was developed for the determination of five pharmaceutical compounds containing thiol group; namely, N-acetylcysteine, captopril, D-penicillamine, 6-mercaptopurine and thioguanine. By utilizing the reaction of the thiol group with silver ions, small amounts of the studied compounds were determined conductometrically in aqueous medium using silver nitrate as titrant. The mean percentage recoveries ranged from [100.3 +/- 0.9] to [100.84 +/- 0.74]. The proposed method was successfully applied to the determination of the studied compounds in dosage forms, and the results were in good agreement with those obtained using the official methods: