Hepatotoxic effect of concomitant administration of acetaminophen [paracetamol] and ethanol in rats

ABSTRACT

Five groups of albino rats, 10 animals each, were used in this work. Animals of group I were given ethanol, those of group II were given acetaminophen, while in group III and IV animals were given both ethanol and acetaminophen concomitantly. The dose of acetaminophen was doubled to animals of group IV. The fifth group was served as a control. Histopathological and histochemical studies of the liver showed that the hepatotoxic effect of acetaminophen or ethanol when each was given alone is more than when both substances were given concomitantly