Congenital morphological and skeletal abnormalities of cyproheptadine hydrochloride [periactin] in rats
MJFCT-Mansoura Journal of Forensic Medicine and Clinical Toxicology. 1993; 1: 57-64
in English
| IMEMR
| ID: emr-29556
ABSTRACT
Cyprotoheptadine hydrochloride [periactin] is one of the antihistaminic drugs which are widely used and frequently described. The aim of this work is to evaluate and find out the effects of periactin on the offsprings of the pregnant rats. It is given orally in a dose of 1.8 mg/kgm to pregnant rats which are divided into 3 groups according to the period of pregnancy. Several morphological and skeletal abnormalities are observed among the offspring. It can be concluded that periactin is a dangerous antihistaminic on the off springs of the rats, hence it is better to be avoided at any time during pregnancy
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rats
/
Abnormalities, Drug-Induced
/
Pregnancy, Animal
/
Histamine H1 Antagonists
/
Animals, Newborn
/
Morphogenesis
Limits:
Animals
Language:
English
Journal:
Mansoura J. Forensic Med. Clin. Toxicol.
Year:
1993
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