Correlation between histopathological and haematological changes produced by lead popllution in mice

ABSTRACT

The effect of repeated drinking of water from El-Manzala Lake through onemonth was investigated in Swiss albino mice. Marked anemia was observed inaddition to increase in total leucocytic count. The pathological changes inmice after drinking polluted water were mostly renal tubular degeneration andnecrosis and less often glomerular atrophy and interstitial nephritis. Theliver and testes were mildly affected, while the other organs showed no abnor malities. These results indicated that pollution caused by sewage disposal in El- Manzala Lake resulted in severe affection of hemopoieticsystem and kidney, and that the level of contamination is sufficient to beconsidered as public health risk