role of enzymatic induction and inhibition on the pathological finding of paracetamol induced hepatic toxicity

ABSTRACT

The effect of phenobarbital, D.D.T. and cobaltous chloride on paracetamol induced hepatic toxicity in rats were studied. The study was conducted in two parts; in the first acute toxic doses were given and in the second longer term administration of lower doses were used. Drugs were given separately and concomitantly with paracetamol to western white rats. The pathological changes were studied and indicated that phenobarbital and D.D.T. have a potentiative toxic effect with paracetamol, while cobaltous chloride has a protective effect for liver tissue insulted with paracetamol, this action is more obvious in the chronic type of toxicity. These findings suggest that the hepatotoxicity induced by paracetamol is mainly due to its metabolites and the microsomal drug metabolism plays an important role in this induced hepatic cell injury