Susceptibility of pathogenic bacteria to augmenting in comparison to other antibiotics

ABSTRACT

A total of 6241 strains of bacteria were isolated from various clinical specimens and tested in vitro to determine the efficacy of amoxycillin calvulanic acid [Augmentin] in comparison with other commonly used antimicrobial agents. This was done by means of disc diffusion method using Muller-Hinton agar susceptibility plates. 74% of the 1994 strains of Enterobacteriaceae, 97% of 1105 Staphylococcus aureus, 62% of 300 Staphylococcus epidermiditis and all the isolates of streptococci, micrococci and enterococci were inhibited by Augmentin. All the 1289 strains of Pseudomonas species, 89% of Serratia marcescens and 79% of Enterobacter species were resistant to Augmentin. However, Augmentin showed considerably increased activity against Escherichia coli, Klebsiella, Proteus and Acinetobacter species as well as staphylococci when compared with ampicillin. Therefore, Augmentin appears to be a very active drug in empirical treatment of infections caused by Gram-positive cocci mainly as well as many of the Gram-negative Enterobacteriaceae