Hepatocellular carcinoma insitu does this lesion exist? A histopathological study of ultrasonography guided needle biopsies of focal solid defects within cirrhotic livers
New Egyptian Journal of Medicine [The]. 1993; 8 (3): 873-7
in English
| IMEMR
| ID: emr-29732
ABSTRACT
Guided needle biopsies were taken from solitary or multiple solid focal hepatic defects [FHDs], detected during imaging of cirrhotic livers by ultrasonography [US] in 216 patients. In 198 patients [91.7%] the biopsies revealed primary hepatic malignancies, predominantly conventional hepatocellular carcinoma [HCC]. In 3 cases [1.4%] the biopsied lesions were macroregenerative nodules with or without mild atypia [MRNs] and in the remaining 15 cases [6.9%] the biopsies revealed macroregenerative modules with diffuse cytological atypia including nuclear irregularities, increased nucleocytoplasmic [N/C] ratio and scattered nucleolar prominence accompanied by thickening of some liver cell plates but without concomitant histological structural changes of hepatic carcinomas. It was suspected that these atypical macroregenerative nodules [AMRNs] may correspond to in situ malignant changes and it was tentatively suggested the term "hepatocellular carcinoma in situ" [HCIS] for these lesions. Similar AMRNs were also detected in association with 6 of the cases readily diagnosed as HCC
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Biopsy, Needle
/
Liver Cirrhosis
Limits:
Humans
Language:
English
Journal:
New Egypt. J. Med.
Year:
1993
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