Effects of beta adrenoceptor blockers and diazepam on blood lipids, glucose, catecholamines and 11 hydroxycorticosteroids of stressed rats

ABSTRACT

This work was conducted to study the effect of oral administration of some B blockers on serum glucose, cholesterol, triglycerides [TG], high density lipoproteins [HDL] and plasma 11 hydroxycorticosteroids, adrenaline [A] and noradrenaline [NA] in stressed rats, as well as their possible interaction with diazepam. Forced immobilization led to significant increase in plasma A, NA, 11 hydroxycorticosteroids, serum glucose, HDL, while TG was significantly decreased. Propranolol pretreatment, 3 weeks before exposure to stress, led to significant reduction of A, NA, 11 hydroxycorticosteroids, glucose, HDL and a rise of TG. Also pindolol pretreatment was followed by increase in HDL and TG in stressed rats. While, atenolol has no significant effect on all parameters. Pretreatment of rats with diazepam alone or in combination with any of B blockers under test induced significant reduction of plasma A and NA. While concomitant administration of propranolol with diazepam decreased significantly the serum glucose, HDL and plasma 11 hydroxycorticosteroids and TG increased. Lastly, pindolol and diazepam increased significantly serum TG and HDL