Exercise capacity in relation to carbohydrate in patients with phosphofructokinase deficiency

ABSTRACT

Twenty seven patients [16 females and 11 males] were studied as subjects for this study. Their ages ranged between 12 and 49 with a mean +/- SD of 27 +/- 6.7 years. Histories of the young patients were confirmed by their parents. Each of the patients had history of life long exercise intolerance with the premature muscle-fatigue, and each reported occasions on which initially fatiguing exercise became more easily tolerated, as in the second-wind phenomenon described in patients with muscle phosphorylase deficiency