Nephrocalcinosis in very low birth weight with family history of renal stones as risk factor

ABSTRACT

A follow up of 23 VLBW survived from 57 very low birth weight neonates [less than 1500 g] and 69 normal newborns [control] were included in the study. Serial renal ultrasonography was carried out to all neonates. Three of VLBW had a family history of renal stones [parturients], 2 of them developed nephrocalcinosis [66.7%]. In the other 20 neonates with VLBW and negative family history of renal stones, none developed nephrocalcinosis. In the control group, 65 had no family history of renal stones, while only 4 had positive family history, none of them developed nephrocalcinosis. It is concluded that nephrocalcinosis is more prevalent in very low weight neonates and is significantly associated with a family history of renal stones [66.7%]. Such neonates should have serial US assessment for the kidney and early blood tests for kidney function should be followed up thoroughly and cautiously after treatment with furosemide. Proper management of parturients with renal stones is mandatory to avoid premature delivery and its complications