Effect of pretreatment with labetalol on gastric secretions altered by ethanol administration

ABSTRACT

The present work was carried out on 80 pylorus ligated rats to study the effects of oral 50% ethanol [1 ml/150 g rat] for a period of 3 hours on gastric secretion and the effect of pre-treatment with graded doses of labetalol administered by intraperitoneal [IP] route before oral ethanol on the same parameters. The collected gastric juice was analyzed for volume [ml], titratable acidity [Meq/l], total acid output [Meq/h], pepsin concentration [mg/ml] and glycoprotein content [mg hexose/ml]