Reactions with [arylmethylene] cycloalkanones 6 Synthesis and deacetylation of 2-acetyl-5-aryl-2,3,6,7,8, 9-hexahdro-5H-thiazolo [23-b] -quinazolin-3-ones
Egyptian Journal of Chemistry. 1983; 26 (6): 461-7
in English
| IMEMR
| ID: emr-3037
ABSTRACT
2-[ARYLMETHYLENE] cycIohexanones condensed with thiourea to give 4-aryl-octahydrcquinazoline-2-thiones II,, which reacted with chloroacetic acid to give the title compounds III. Compounds III suffer deacetylation when reacted with aromatic aldehydes, arene-diazonium salts and also when subjected to Mannich reaction to give the following compounds, respectively; 5-aryl-2-[arylmethlene]-2, 3,6,7,8,9, hexahydro-5H - thiazolo [2,3-b] - quinazolin-3-ones [IV], 5-aryl-2-[arylhydrazono]-2,3, 6,7,8,9-hexahydro-5H-thiazolo [2,3-b] -quinazolin-3-ones [V] and 5-aryl-2 - [aminomethyl] - 23,6,7,8,9-hexahydro-5H-thiazolo[2,3-b] quinazolin-3-ones [VI]
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Quinazolines
/
Thiourea
/
Aldehydes
Language:
English
Journal:
Egypt. J. Chem.
Year:
1983
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